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Article

Introduction of Premature Stop Codons as an Evolutionary Strategy To Rescue Signaling Network Function.

ACS synthetic biology - 17 Mar 2017

Kompella Purnima S, Moses Alan M, Peisajovich Sergio G

Abstract excerpt

The cellular concentrations of key components of signaling networks are tightly regulated, as deviations from their optimal ranges can have negative effects on signaling function. For example, overexpression of the yeast mating pathway mitogen-activated protein kinase (MAPK) Fus3 decreases pathway output, in part by sequestering individual components away from functional multiprotein complexes. Using a synthetic...

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PMID: 27935292
DOI: 10.1021/acssynbio.6b00142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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