Article
Mapping pathways and phenotypes by systematic gene overexpression.
Molecular cell - 3 Feb 2006
Sopko Richelle, Huang Dongqing, Preston Nicolle, Chua Gordon, Papp Balázs, Kafadar Kimberly, Snyder Mike, Oliver Stephen G, Cyert Martha, Hughes Timothy R, Boone Charles, Andrews Brenda
Abstract excerpt
Many disease states result from gene overexpression, often in a specific genetic context. To explore gene overexpression phenotypes systematically, we assembled an array of 5280 yeast strains, each containing an inducible copy of an S. cerevisiae gene, covering >80% of the genome. Approximately 15% of the overexpressed genes (769) reduced growth rate. This gene set was enriched for cell cycle-regulated genes,...
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