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Article

Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping.

Molecular cell - 18 Jan 2018

Jaeger Philipp A, Ornelas Lilia, McElfresh Cameron, Wong Lily R, Hampton Randolph Y, Ideker Trey

Abstract excerpt

We have developed a highly parallel strategy, systematic gene-to-phenotype arrays (SGPAs), to comprehensively map the genetic landscape driving molecular phenotypes of interest. By this approach, a complete yeast genetic mutant array is crossed with fluorescent reporters and imaged on membranes at high density and contrast. Importantly, SGPA enables quantification of phenotypes that are not readily detectable in...

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Identifiers

PMID: 29351850
DOI: 10.1016/j.molcel.2017.12.016
PMCID: PMC5777277

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CDK8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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