Manipulating gene expression levels in mammalian cell factories: An outline of synthetic molecular toolboxes to achieve multiplexed control

Abstract excerpt

Cells, both of prokaryotic and eukaryotic origin, have developed dedicated molecular mechanisms to tightly control expression levels of their genes where the specific transcriptomic signature across all genes eventually determines the cell phenotype. Modulating cellular phenotypes is of major interest, either to study their role in disease or to reprogram cells for the manufacture of recombinant products, such as...

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