Article
Functional discovery via a compendium of expression profiles.
Cell - 7 Jul 2000
Hughes T R, Marton M J, Jones A R, Roberts C J, Stoughton R, Armour C D, Bennett H A, Coffey E, Dai H, He Y D, Kidd M J, King A M, Meyer M R, Slade D, Lum P Y, Stepaniants S B, Shoemaker D D, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend S H
Abstract excerpt
Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental problem in biology. Here, we describe how a single assay can be used to monitor hundreds of different cellular functions simultaneously. We constructed a reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae, and we show that the cellular...
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