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Article

Model-guided mechanism discovery and parameter selection for directed evolution.

Applied microbiology and biotechnology - 1 Dec 2019

Stainbrook Sarah C, Tyo Keith E J

Abstract excerpt

Directed evolution is frequently applied to identify genetic variants with improvements in a single or multiple properties. When used to improve multiple properties simultaneously, a common strategy is to apply alternating rounds of selection criteria to enrich for variants with each desirable trait. In particular, counterselection, or selection against undesired traits rather than for desired ones, has been...

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Identifiers

PMID: 31686141
DOI: 10.1007/s00253-019-10179-5
PMCID: PMC8186486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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