Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents.

PloS one - 1 Jan 2011

Sharp Elizabeth R, Willberg Christian B, Kuebler Peter J, Abadi Jacob, Fennelly Glenn J, Dobroszycki Joanna, Wiznia Andrew A, Rosenberg Michael G, Nixon Douglas F

Abstract excerpt

BACKGROUND: HIV-1 vertically infected children in the USA are living into adolescence and beyond with the widespread use of antiretroviral drugs. These patients exhibit striking differences in the rate of HIV-1 disease progression which could provide insights into mechanisms of control. We hypothesized that differences in the pattern of immunodomination including breadth, magnitude and polyfunctionality of HIV-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokines
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Degranulation

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HLA Antigens

Share to Immunodominant Epitopes

Share to Infectious Disease Transmission, Vertical

Share to Peptides

Source

Open in PubMed Open full text

Identifiers

PMID: 21818255
DOI: 10.1371/journal.pone.0021135
PMCID: PMC3139570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents.PMID 21818255Read ↗

Immunodominance of HIV-1-specific CD8+ T-cell responses in acute HIV-1 infection: at the crossroads of viral and host geneticsSemantic proximity Read ↗

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.Semantic proximity Read ↗

Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents.Semantic proximity Read ↗

T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I alleles.Semantic proximity Read ↗

Early Gag Immunodominance of the HIV-Specific T-Cell Response during Acute/Early Infection Is Associated with Higher CD8 <sup>+</sup> T-Cell Antiviral Activity and Correlates with Preservation of the CD4 <sup>+</sup> T-Cell CompartmentSemantic proximity Read ↗

Comparisons of CD8<sup>+</sup>T Cells Specific for Human Immunodeficiency Virus, Hepatitis C Virus, and Cytomegalovirus Reveal Differences in Frequency, Immunodominance, Phenotype, and Interleukin-2 ResponsivenessSemantic proximity Read ↗

Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen loadSemantic proximity Read ↗

Relative contribution of HIV-specific functional lymphocyte subsets restricted by protective and non-protective HLA alleles.Semantic proximity Read ↗

Antiretroviral therapy reduces the magnitude and T cell receptor repertoire diversity of HIV-specific T cell responses without changing T cell clonotype dominance.Semantic proximity Read ↗

Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple EthnicitiesSemantic proximity Read ↗

Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.Semantic proximity Read ↗

Definition of the viral targets of protective HIV-1-specific T cell responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.