Article
Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor.
The Journal of cell biology - 19 Nov 2007
Baumgärtner Petra, Geiger Margarethe, Zieseniss Susanne, Malleier Julia, Huntington James A, Hochrainer Karin, Bielek Edith, Stoeckelhuber Mechthild, Lauber Kirsten, Scherfeld Dag, Schwille Petra, Wäldele Katja, Beyer Klaus, Engelmann Bernd
Abstract excerpt
Although their contribution remains unclear, lipids may facilitate noncanonical routes of protein internalization into cells such as those used by cell-penetrating proteins. We show that protein C inhibitor (PCI), a serine protease inhibitor (serpin), rapidly transverses the plasma membrane, which persists at low temperatures and enables its nuclear targeting in vitro and in vivo. Cell membrane translocation of...
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