Article

A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of <i>Chlamydia trachomatis</i>

2024-08-02

Abstract excerpt

<h4>ABSTRACT</h4> The bacterial pathogen Chlamydia trachomatis employs the effector CpoS to suppress a host defense response that aborts intracellular bacterial growth by inducing host cell death. While conducting a CRISPR knock-out screen for genes contributing to this response, we uncovered a mutant deficient for CpoS to display a markedly increased reliance on host cellular ceramide synthesis, compensating fo...

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Literature Corpus work: 622d795e-3c0f-5828-904c-1fd0ba1a2df9
DOI: 10.1101/2024.08.02.606337

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