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Article

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42.

Molecular systems biology - 15 Mar 2011

Misselwitz Benjamin, Dilling Sabrina, Vonaesch Pascale, Sacher Raphael, Snijder Berend, Schlumberger Markus, Rout Samuel, Stark Manuel, von Mering Christian, Pelkmans Lucas, Hardt Wolf-Dietrich

Abstract excerpt

The pathogen Salmonella Typhimurium is a common cause of diarrhea and invades the gut tissue by injecting a cocktail of virulence factors into epithelial cells, triggering actin rearrangements, membrane ruffling and pathogen entry. One of these factors is SopE, a G-nucleotide exchange factor for the host cellular Rho GTPases Rac1 and Cdc42. How SopE mediates cellular invasion is incompletely understood. Using...

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Identifiers

PMID: 21407211
DOI: 10.1038/msb.2011.7
PMCID: PMC3094068

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