Article

HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins

2018-07-23

Abstract excerpt

Protein therapeutics represent a significant and growing component of the modern pharmacopeia, but their potential to treat human disease is limited because most proteins fail to traffic across biological membranes. Recently, we discovered that cell-permeant miniature proteins (CPMPs) containing a precisely defined, penta-arginine motif traffic readily to the cytosol and nucleus with efficiencies that rival those...

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Identifiers and source

Literature Corpus work: 1673f35c-eee5-5c57-b2e9-6a844e118708
DOI: 10.1101/374926

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