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Article

Structural basis for tuning activity and membrane specificity of bacterial cytolysins.

Nature communications - 16 Nov 2020

Shah Nita R, Voisin Tomas B, Parsons Edward S, Boyd Courtney M, Hoogenboom Bart W, Bubeck Doryen

Abstract excerpt

Cholesterol-dependent cytolysins (CDCs) are pore-forming proteins that serve as major virulence factors for pathogenic bacteria. They target eukaryotic cells using different mechanisms, but all require the presence of cholesterol to pierce lipid bilayers. How CDCs use cholesterol to selectively lyse cells is essential for understanding virulence strategies of several pathogenic bacteria, and for repurposing CDCs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33199689
DOI: 10.1038/s41467-020-19482-6
PMCID: PMC7669874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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