Article

Pathogenic Bacteria Remotely Remodel Host Membrane Mechanics via Extracellular Vesicles to subvert Phagosome Maturation and Promote infection

2025-12-19

Abstract excerpt

Bacterial extracellular vesicles (BEVs) are known to enhance infection susceptibility in vivo, yet the mechanistic basis for this remote preconditioning of host cells is unknown. Here, we discover an evolutionarily conserved, lipid-driven physical mechanism by which pathogenic bacterial EVs systemically arrest phagosome maturation in bystander host cells. Using live-cell fluorescence lifetime imaging, in vitro re...

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Literature Corpus work: 8cd08d08-ac66-53b6-b59f-1c28c87f3f10
DOI: 10.64898/2025.12.17.694930

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