Article

Lipoproteins modulate the uptake and biological function of cationic cell-penetrating peptides across the animal lineage.

2026-08-24

Abstract excerpt

Cationic cell-penetrating peptides (+CPPs) are pervasive killer peptides produced by all animals and found in innate immune systems, venoms and neurodegenerative diseases. Despite their ubiquity, the mechanisms underlying their uptake remain opaque and intensely debated. Here, we interrogate +CPPs spanning 600 million years of animal evolution and identify endocytosis as a conserved/convergent uptake mechanism acr...

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Literature Corpus work: e0d72aee-11fc-5399-aeb4-602aafb2974d
DOI: 10.64898/2026.08.23.746575

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