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Article

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2007

Samuelson A V, Klimczak R R, Thompson D B, Carr C E, Ruvkun G

Abstract excerpt

A systematic genome-wide RNA interference screen was performed in the Caenorhabditis elegans lin-15b;eri-1 strain, which has an enhanced response to double-stranded RNA including the nervous system, to identify life-span regulatory factors. In total, 16,757 genes were examined, revealing 115 gene inactivations that extended life span. A more stringent longitudinal analysis revealed 18 gene inactivations that...

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PMID: 18419309
DOI: 10.1101/sqb.2007.72.068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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