Article
Pin1 acts catalytically to promote a conformational change in Cdc25.
Molecular cell - 1 May 2001
Stukenberg P T, Kirschner M W
Abstract excerpt
Pin1 is an essential protein that can peptidyl-prolyl-isomerize small phosphopeptides. It has been suggested that Pin1 regulates entry into mitosis by catalyzing the cis/trans-isomerization of prolines on critical protein substrates in response to phosphorylation. We show that Pin1 catalytically generates a conformational change on the mitotic phosphatase Cdc25, as assayed by limited protease digestion,...
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