Article

Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks

2022-03-29

Abstract excerpt

<h4>Background</h4> Sitting at the interface of gene expression and host-pathogen interaction, polymerase associated factor 1 complex (PAF1C) is a rising player in the innate immune response. The complex localizes to the nucleus and associates with chromatin to modulate RNA polymerase II (RNAPII) elongation of gene transcripts. Performing this function at both proximal and distal regulatory elements, PAF1C intera...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 229f28f2-1894-5e08-a072-593a666a2611
DOI: 10.1101/2022.03.28.485548

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networksDOI 10.1101/2022.03.28.485548Read

Native, Spatiotemporal Profiling of the Global Human RegulomeSemantic proximity Read

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.Semantic proximity Read

Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19Semantic proximity Read

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation.Semantic proximity Read

Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes.Semantic proximity Read

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Semantic proximity Read

Innate immune epigenomic landscape following controlled human influenza virus infectionSemantic proximity Read

Spatiotemporal Analysis of Lung Immune Dynamics in Lethal <i>Coccidioides posadasii</i> InfectionSemantic proximity Read

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seqSemantic proximity Read

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seqSemantic proximity Read

A whole genome screen for HIV restriction factorsSemantic proximity Read

Paf1p, an RNA polymerase II-associated factor in Saccharomyces cerevisiae, may have both positive and negative roles in transcription.Semantic proximity Read