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Article

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2002

Liou Yih-Cherng, Ryo Akihide, Huang Han-Kuei, Lu Pei-Jung, Bronson Roderick, Fujimori Fumihiro, Uchida Takafumi, Hunter Tony, Lu Kun Ping

Abstract excerpt

Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function of a subset of these phosphorylated proteins is regulated by the prolyl isomerase Pin1 through isomerization of phosphorylated Ser/Thr-Pro bonds. Although young Pin1(-/-) mice have been previously shown to develop normally, we show here that they displayed a range of...

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Identifiers

PMID: 11805292
DOI: 10.1073/pnas.032404099
PMCID: PMC122191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.PMID 11805292Read ↗

The Loss of PIN1 Deregulates Cyclin E and Sensitizes Mouse Embryo Fibroblasts to Genomic InstabilitySemantic proximity Read ↗

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The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

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A role for Pin1 in mammalian germ cell development and spermatogenesis.Semantic proximity Read ↗

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.Semantic proximity Read ↗

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.Semantic proximity Read ↗

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.Semantic proximity Read ↗

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins.Semantic proximity Read ↗

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