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Article

The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2006

Frey Ulrich H, Nückel Holger, Sellmann Ludger, Siemer Dörte, Küppers Ralf, Dürig Jan, Dührsen Ulrich, Siffert Winfried

Abstract excerpt

PURPOSE: B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of monoclonal mature B cells. The G protein Galphas subunit has been linked to proapoptotic processes in cancer cell lines. The TT genotype of the GNAS1 T393C polymorphism is associated with increased Galphas transcript levels and a more favorable clinical course in different solid cancers. EXPERIMENTAL DESIGN: We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 17020971
DOI: 10.1158/1078-0432.CCR-06-0288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia.PMID 17020971Read ↗

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