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Article

GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2005

Frey Ulrich H, Alakus Hakan, Wohlschlaeger Jeremias, Schmitz Klaus J, Winde Günther, van Calker Hans G, Jöckel Karl-Heinz, Siffert Winfried, Schmid Kurt W

Abstract excerpt

PURPOSE: Signaling via the G protein Galpha s pathway is linked to proapoptotic processes in cancer cell lines. We have recently shown an association between the GNAS1 T393C polymorphism and disease progression in patients with bladder cancer with homozygous TT genotypes displaying increased transcription of Galpha s and a more favorable clinical course compared with C-allele carriers. EXPERIMENTAL DESIGN: In the...

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PMID: 16033819
DOI: 10.1158/1078-0432.CCR-05-0472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer.PMID 16033819Read ↗

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