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Article

The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia.

Leukemia & lymphoma - 1 Oct 2003

Nückel Holger, Frey Ulrich, Aralh Nese, Dürig Jan, Dührsen Ulrich, Siffert Winfried

Abstract excerpt

A C825T polymorphism has been described in the GNB3 gene which encodes the Gbeta3 subunit of heterotrimeric G proteins. The GNB3 825T allele is predictive of enhanced Gi protein activation. This study was performed to correlate genotypes of the C825T polymorphism with various clinical aspects of chronic lymphocytic leukaemia (B-CLL). The GNB3 genotype distribution in B-CLL patients was similar to that in other...

Topics

Aged
Antineoplastic Agents
Female
Genotype
Heterotrimeric GTP-Binding Proteins
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Male
Middle Aged
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Source

Identifiers

PMID: 14692527
DOI: 10.1080/1042819031000111017

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia.PMID 14692527Read ↗

The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response.Semantic proximity Read ↗

The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

Association of the GNB3 825T-allele with better survival in patients with glioblastoma multiforme.Semantic proximity Read ↗

The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer.Semantic proximity Read ↗

Association study of the G-protein beta3 subunit C825T polymorphism with disease progression an overall survival in patients with head and neck squamous cell carcinoma.Semantic proximity Read ↗

Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit.Semantic proximity Read ↗

Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit.Semantic proximity Read ↗

G Protein β3 subunit gene C825T polymorphism and its association with the presence and clinicopathological characteristics of prostate cancer.Semantic proximity Read ↗

Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer.Semantic proximity Read ↗

A polymorphism in the G protein beta3-subunit gene is associated with bone metastasis risk in breast cancer patients.Semantic proximity Read ↗

The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia.Semantic proximity Read ↗

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