Article
The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma.
Breast cancer research and treatment - 1 Nov 2007
Otterbach Friedrich, Callies Rainer, Frey Ulrich H, Schmitz Klaus J, Wreczycki Christof, Kimmig Rainer, Siffert Winfried, Schmid Kurt W
Abstract excerpt
The GNAS1 locus encodes the G(alpha)s protein which stimulates the formation of cyclic AMP (cAMP). Subsequently the cAMP pathway mediates various pleiotropic effects including regulation of apoptosis and proliferation. We have recently shown that genotypes of the single nucleotide polymorphism (SNP) T393C in the gene GNAS1 are associated with survival of patients suffering from bladder, renal cell and colorectal...
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