Article
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007
Hong Sunhwa, Cho Young-Wook, Yu Li-Rong, Yu Hong, Veenstra Timothy D, Ge Kai
Abstract excerpt
Covalent modifications of histones, such as acetylation and methylation, play important roles in the regulation of gene expression. Histone lysine methylation has been implicated in both gene activation and repression, depending on the specific lysine (K) residue that becomes methylated and the state of methylation (mono-, di-, or trimethylation). Methylation on K4, K9, and K36 of histone H3 has been shown to be...
Topics
- Animals
- Catalysis
- Cell Line
- Chlorocebus aethiops
- Gene Expression Regulation, Enzymologic
- Histone Demethylases
- Histones
- Humans
- Jumonji Domain-Containing Histone Demethylases
- Lysine