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Article

The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.

Molecular and cellular biology - 1 May 2010

Herz Hans-Martin, Madden Laurence D, Chen Zhihong, Bolduc Clare, Buff Eugene, Gupta Ravi, Davuluri Ramana, Shilatifard Ali, Hariharan Iswar K, Bergmann Andreas

Abstract excerpt

Trimethylated lysine 27 of histone H3 (H3K27me3) is an epigenetic mark for gene silencing and can be demethylated by the JmjC domain of UTX. Excessive H3K27me3 levels can cause tumorigenesis, but little is known about the mechanisms leading to those cancers. Mutants of the Drosophila H3K27me3 demethylase dUTX display some characteristics of Trithorax group mutants and have increased H3K27me3 levels in vivo....

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Identifiers

PMID: 20212086
DOI: 10.1128/MCB.01633-09
PMCID: PMC2863695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.PMID 20212086Read ↗

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.Semantic proximity Read ↗

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