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Article

Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila.

Genetics - 1 Feb 2018

Copur Ömer, Müller Jürg

Abstract excerpt

The trimethylation of histone H3 at lysine 27 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2) is essential for the repression of Polycomb target genes. However, the role of enzymatic demethylation of H3K27me3 by the KDM6-family demethylases Utx, Uty, and JmjD3 is less clear. Studies in both mice and worms led to the proposal that KDM6 proteins, but not their H3K27me3 demethylase activity, is critical for...

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Identifiers

PMID: 29247011
DOI: 10.1534/genetics.117.300421
PMCID: PMC5788527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila.PMID 29247011Read ↗

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.Semantic proximity Read ↗

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.Semantic proximity Read ↗

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.Semantic proximity Read ↗

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.Semantic proximity Read ↗

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation.Semantic proximity Read ↗

UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome.Semantic proximity Read ↗

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.Semantic proximity Read ↗

Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.Semantic proximity Read ↗

The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila.Semantic proximity Read ↗

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UTX coordinates steroid hormone-mediated autophagy and cell death.Semantic proximity Read ↗

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