Article

Epigenetic Regulation of Chondrogenesis: JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue Engineering

2025-06-08

Abstract excerpt

Osteoarthritis is a major cause of disability in older adults, and among the promising therapeutic strategies, cartilage tissue engineering shows great potential. Histone methylation plays a critical role in cartilage development, making it an appealing target for improving cartilage engineering protocols. In this study, we evaluated the roles of JMJD3 (KDM6B) and UTX (KDM6A), both demethylases of histone H3 at ly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7e64c3c-07b5-5b55-93ee-a4cf445fa287
DOI: 10.1101/2025.06.06.658259

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic Regulation of Chondrogenesis: JMJD3 and UTX as Key Targets for Gene-Modified Mesenchymal Stem Cell Therapy in Cartilage Tissue EngineeringDOI 10.1101/2025.06.06.658259Read

JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice.Semantic proximity Read

Transforming Growth Factor-β-Induced KDM4B Promotes Chondrogenic Differentiation of Human Mesenchymal Stem CellsSemantic proximity Read

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1Semantic proximity Read

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.Semantic proximity Read

Hemizygous mutation of Jmjd3 in muscle stem cells increases H3K27 methylation on Pax7 leading to impaired myogenesis.Semantic proximity Read

Spatial transcriptomics defines the mechanisms of hiPSC-derived stem cell-mediated repair in human articular cartilageSemantic proximity Read

Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytesSemantic proximity Read

New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.Semantic proximity Read

Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cellsSemantic proximity Read

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic ImplicationsSemantic proximity Read

The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage qualitySemantic proximity Read

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.Semantic proximity Read