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Article

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.

PLoS genetics - 1 Aug 2014

Shpargel Karl B, Starmer Joshua, Yee Della, Pohlers Michael, Magnuson Terry

Abstract excerpt

The early mammalian embryo utilizes histone H3 lysine 27 trimethylation (H3K27me3) to maintain essential developmental genes in a repressive chromatin state. As differentiation progresses, H3K27me3 is removed in a distinct fashion to activate lineage specific patterns of developmental gene expression. These rapid changes in early embryonic chromatin environment are thought to be dependent on H3K27 demethylases....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25101834
DOI: 10.1371/journal.pgen.1004507
PMCID: PMC4125042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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