Article
Influence of a nonfragile FHIT transgene on murine tumor susceptibility.
Cytogenetic and genome research - 1 Jan 2007
McCorkell K A, Mancini R, Siprashvili Z, Barnoski B L, Iliopoulos D, Siracusa L D, Zanesi N, Croce C M, Fong L Y Y, Druck T, Huebner K
Abstract excerpt
FHIT, at a constitutively active chromosome fragile site, is often a target of chromosomal aberrations and deletion in a large fraction of human tumors. Inactivation of murine Fhit allelessignificantly increases susceptibility of mice to spontaneous and carcinogen-induced tumorigenesis. In this study, transgenic mice, carrying a human FHIT cDNA under control of the endogenous promoter, were produced to determine...
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