Article
The tumor spectrum in FHIT-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001
Zanesi N, Fidanza V, Fong L Y, Mancini R, Druck T, Valtieri M, Rüdiger T, McCue P A, Croce C M, Huebner K
Abstract excerpt
Mice carrying one inactivated Fhit allele (Fhit +/- mice) are highly susceptible to tumor induction by N-nitrosomethylbenzylamine, with 100% of Fhit +/- mice exhibiting tumors of the forestomach/squamocolumnar junction vs. 25% of Fhit +/+ controls. In the current study a single N-nitrosomethylbenzylamine dose was administered to Fhit +/+, +/-, and -/- mice to compare carcinogen susceptibility in +/- and -/-...
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