An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice.

doi:10.1083/jcb.122.1.199

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Article

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice.

The Journal of cell biology - 1 Jul 1993

Stöcklin E, Botteri F, Groner B

Abstract excerpt

The pathogenicity of the human c-erbB-2 oncogene was evaluated in transgenic mice. A DNA sequence comprising the promoter-enhancer region of the MMTV LTR and a constitutively activated allele of the human c-erbB-2 growth factor receptor gene was introduced into the germ line of mice. Expression o...

Topics

Alleles
Animals
Death
Epididymis
Female
Gene Expression Regulation
Genetic Vectors
Humans
Kidney
Longevity
Lung
Male
Mammary Glands, Animal
Mammary Tumor Virus, Mouse
Mice
Mice, Transgenic
Organ Specificity
Precancerous Conditions

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