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Article

Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.

Cancer research - 1 Aug 2005

Zanesi Nicola, Mancini Rita, Sevignani Cinzia, Vecchione Andrea, Kaou Mohamed, Valtieri Mauro, Calin George A, Pekarsky Yuri, Gnarra James R, Croce Carlo M, Huebner Kay

Abstract excerpt

The FHIT gene plays important roles in cancer development, including lung cancers, in which the Fhit protein is frequently lost. To determine if Fhit-deficient mice exhibit increased susceptibility to carcinogen-induced lung cancer, mice were treated with the pulmonary carcinogen 4-methylnitrosamino-1-3-pyridyl-1-butanone. Wild-type and Fhit-deficient animals did not exhibit significantly different frequencies of...

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Source

Identifiers

PMID: 16061637
DOI: 10.1158/0008-5472.CAN-05-1128

Genes

FHIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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