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Article

Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.

Japanese journal of cancer research : Gann - 1 Jul 2002

Asamoto Makoto, Toriyama-Baba Hiroyasu, Ohnishi Takamasa, Naito Akihiro, Ota Tomonori, Ando Akira, Ochiya Takahiro, Tsuda Hiroyuki

Abstract excerpt

A transgenic rat line carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region, has been established in our laboratory (Hras128 rats), and shown to be highly susceptible to induction of mammary and urinary bladder tumors. Mutation analysis of induced lesions indicated the majority to contain some but not all cells with transgene mutation. In the present study, the...

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Identifiers

PMID: 12149139
DOI: 10.1111/j.1349-7006.2002.tb01315.x
PMCID: PMC5927067

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.PMID 12149139Read ↗

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