Article
Genotyping of CYP3A5 polymorphisms among Bulgarian patients with sporadic colorectal cancer and controls.
Onkologie - 1 Nov 2007
Petrova Darinka Todorova, Yaramov Nikolay, Toshev Svetoslav, Nedeva Petya, Maslyankov Svilen, von Ahsen Nicolas, Oellerich Michael, Toncheva Draga
Abstract excerpt
BACKGROUND: The purpose of the study was to genotype four polymorphisms in CYP3A5 (CYP3A5*2, CYP3A5*3, CYP3A5*3B, and CYP3A5*6) for a possible association between individual genetic variations and susceptibility to colorectal cancer. Another point of interest was to conduct a comprehensive analysis in tumor and normal intestine tissue from the same patient, searching for somatic hotspots. MATERIAL AND METHODS: In...
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