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Article

No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients.

Journal of cancer research and clinical oncology - 1 Mar 2008

Petrova Darinka Todorova, Nedeva Petya, Maslyankov Svilen, Toshev Svetoslav, Yaramov Nikolay, Atanasova Srebrena, Toncheva Draga, Oellerich Michael, von Ahsen Nicolas

Abstract excerpt

PURPOSE: Variation in genetic factors together with xenobiotic exposure may result in increased risk of colorectal cancer. The P-glycoprotein (P-gp) is highly expressed in the apical membrane of enterocytes, where it pumps xenobiotics from the enterocytes back into the intestinal lumen. Thus, polymorphisms that reduce the activity of the MDR1 (ABCB1) efflux pump are potential risk factors for colorectal...

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Identifiers

PMID: 17674045
DOI: 10.1007/s00432-007-0279-9

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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