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Article

Polymorphic expression of UDP-glucuronosyltransferase UGTlA gene in human colorectal cancer.

PloS one - 1 Jan 2013

Wang Min, Sun De-Feng, Wang Shuai, Qing Ying, Chen Shuo, Wu Dong, Lin Ying-Min, Luo Ji-Zhuang, Li Yan-Qing

Abstract excerpt

BACKGROUND: Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity. Reduced capacity of glucuronidation is correlated with the development of colorectal cancer. Therefore, we sought to explore polymorphism of UGTlA gene in human colorectal...

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Identifiers

PMID: 23468910
DOI: 10.1371/journal.pone.0057045
PMCID: PMC3584141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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