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Article

Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.

BMC cancer - 2 Jul 2007

Gervasini Guillermo, García-Martín Elena, Ladero José M, Pizarro Rosa, Sastre Javier, Martínez Carmen, García Monserrat, Diaz-Rubio Manuel, Agúndez José A G

Abstract excerpt

BACKGROUND: Drug-metabolizing enzymes play a role in chemical carcinogenesis through enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene polymorphisms of several cytochrome P450 enzymes in digestive cancer risk has been extensively investigated. However, the drug-metabolizing enzymes with the broader substrate specificity, CYP3A4 and CYP3A5, have not been analyzed so far....

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Identifiers

PMID: 17605821
DOI: 10.1186/1471-2407-7-118
PMCID: PMC1931602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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