Article
Common single nucleotide polymorphisms in the vascular endothelial growth factor gene and colorectal cancer risk.
Journal of cancer research and clinical oncology - 1 May 2008
Hofmann Guenter, Langsenlehner Uwe, Renner Wilfried, Langsenlehner Tanja, Yazdani-Biuki Babak, Clar Heimo, Gerger Armin, Wehrschuetz Martin, Samonigg Hellmut, Krippl Peter
Abstract excerpt
PURPOSE: Tumor growth requires the formation of new blood vessels, a phenomenon known as angiogenesis. The most important regulator of angiogenesis is vascular endothelial growth factor (VEGF). Several common polymorphisms in the VEGF-gene have been associated with different VEGF expression, production and plasma levels according to allele status, and influence the risk of developing different types of cancer....
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Genetic Predisposition to Disease
- Humans
- Male