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Article

Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.

Cellular and molecular life sciences : CMLS - 1 Feb 2008

Gereben B, Zeöld A, Dentice M, Salvatore D, Bianco A C

Abstract excerpt

The thyroid hormone plays a fundamental role in the development, growth, and metabolic homeostasis in all vertebrates by affecting the expression of different sets of genes. A group of thioredoxin fold-containing selenoproteins known as deiodinases control thyroid hormone action by activating or inactivating the precursor molecule thyroxine that is secreted by the thyroid gland. These pathways ensure regulation...

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Identifiers

PMID: 17989921
DOI: 10.1007/s00018-007-7396-0
PMCID: PMC11131710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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