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Thyroid Hormone Deiodinases: Dynamic Switches in Developmental Transitions

7 May 2021

Abstract excerpt

Thyroid hormones exert pleiotropic, essential actions in mammalian, including human, development. These actions depend on provision of thyroid hormones in the circulation but also to a remarkable extent on deiodinase enzymes in target tissues that amplify or deplete the local concentration of the primary active form of the hormone T3 (3,5,3'-triiodothyronine), the high affinity ligand for thyroid hormone...

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PMID: 33963379
DOI: 10.1210/endocr/bqab091

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