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Genetic disorders of thyroid development, hormone biosynthesis and signalling

24 Aug 2022

Abstract excerpt

Development and differentiation of the thyroid gland is directed by expression of specific transcription factors in the thyroid follicular cell which mediates hormone biosynthesis. Membrane transporters are rate-limiting for cellular entry of thyroid hormones (TH) (T4 and T3) into some tissues, with selenocysteine-containing, deiodinase enzymes (DIO1 and DIO2) converting T4 to the biologically active hormone T3....

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PMID: 35999191
DOI: 10.1111/cen.14817

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