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Article

Deiodinases and Cancer

4 Feb 2021

Abstract excerpt

Hormones are key drivers of cancer development, and alteration of the intratumoral concentration of thyroid hormone (TH) is a common feature of many human neoplasias. Besides the systemic control of TH levels, the expression and activity of deiodinases constitute a major mechanism for the cell-autonomous, prereceptoral control of TH action. The action of deiodinases ensures tight control of TH availability at...

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PMID: 33539515
DOI: 10.1210/endocr/bqab016

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