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Article

Evolution of cagA Oncogene of Helicobacter pylori through Recombination

11 Aug 2011

Abstract excerpt

Helicobacter pylori is a gastric pathogen that infects half the human population and causes gastritis, ulcers, and cancer. The cagA gene product is a major virulence factor associated with gastric cancer. It is injected into epithelial cells, undergoes phosphorylation by host cell kinases, and perturbs host signaling pathways. CagA is known for its geographical, structural, and functional diversity in the...

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PMID: 21853141
DOI: 10.1371/journal.pone.0023499

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