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Article

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.

Molecular genetics and genomics : MGG - 1 Feb 2008

García-Rubio María, Chávez Sebastián, Huertas Pablo, Tous Cristina, Jimeno Sonia, Luna Rosa, Aguilera Andrés

Abstract excerpt

THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and plays a role in preventing the transcription-associated genetic instability. THO is composed of Tho2, Hpr1, Mft1 and Thp2 subunits, which associate with the Sub2-Yra1 export factors and Tex1 to form the TREX complex. To compare the functional relevance of the different THO/TREX subunits, we determined the effect of their null mutations...

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PMID: 17960421
DOI: 10.1007/s00438-007-0301-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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