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Article

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.

Nucleic acids research - 1 Jul 2009

Gómez-González Belén, Aguilera Andrés

Abstract excerpt

To get further insight into the effect that THO/TREX and R-loops have in transcription-associated recombination and transcription, we analyzed the ability to form R-loops of hpr1-101, a THO mutation that impairs transcription and mRNP biogenesis without triggering hyper-recombination. Human AID, a cytidine deaminase that acts on ssDNA displaced by RNA-DNA hybrids, strongly induced both hyper-recombination and...

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Identifiers

PMID: 19451165
DOI: 10.1093/nar/gkp385
PMCID: PMC2715242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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