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Article

A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.

Molecular genetics and genomics : MGG - 1 Oct 2008

Jimeno Sonia, García-Rubio Maria, Luna Rosa, Aguilera Andrés

Abstract excerpt

Hrs1/Med3, a component of the Mediator involved in transcription initiation, was previously isolated as a suppressor of hpr1Delta hyper-recombination linked to transcription elongation. Here we show that hrs1Delta-mediated suppression is specific of transcription-associated hyper-recombination (T...

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Share to Genomic Instability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18682986
DOI: 10.1007/s00438-008-0368-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18682986-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.PMID 18682986Read ↗

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Defective nucleotide excision repair in yeast hpr1 and tho2 mutants.Semantic proximity Read ↗

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.Semantic proximity Read ↗

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.Semantic proximity Read ↗

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Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.Semantic proximity Read ↗

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