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Article

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.

Molecular and cellular biology - 1 Apr 2006

Wellinger Ralf E, Prado Félix, Aguilera Andrés

Abstract excerpt

THO/TREX is a conserved, eukaryotic protein complex operating at the interface between transcription and messenger ribonucleoprotein (mRNP) metabolism. THO mutations impair transcription and lead to increased transcription-associated recombination (TAR). These phenotypes are dependent on the nascent mRNA; however, the molecular mechanism by which impaired mRNP biogenesis triggers recombination in THO/TREX mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16581804
DOI: 10.1128/MCB.26.8.3327-3334.2006
PMCID: PMC1446968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.PMID 16581804Read ↗

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