Article
Defective nucleotide excision repair in yeast hpr1 and tho2 mutants.
Nucleic acids research - 15 May 2002
González-Barrera Sergio, Prado Félix, Verhage Richard, Brouwer Jaap, Aguilera Andrés
Abstract excerpt
Nucleotide excision repair (NER) and transcription are intimately related. First, TFIIH has a dual role in transcription initiation and NER and, secondly, transcription leads to more efficient repair of damage present in transcribed sequences. It is thought that elongating RNAPII, stalled at a DNA lesion, is used for the loading of the NER machinery in a process termed transcription-coupled repair (TCR)....
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