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Article

The THO complex in Schizosaccharomyces pombe-dissecting the composition and functional hierarchy.

FEBS letters - 1 Jun 2026

He Wenchong, Huang Chengzhi, Huang Qi, Ma Wei

Abstract excerpt

The THO complex was initially identified in Saccharomyces cerevisiae with five subunits: Hpr1p, Tho2p, Mft1p, Thp2p, and Tex1p. It plays a major role in mRNA processing and nuclear export. Here, we aimed to identify the putative homologs in Schizosaccharomyces pombe. Among eight candidates, genetic analysis showed tho1, tho2, and pci2 are essential, while mutants of tho5 and tho7 exhibited growth defects along...

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PMID: 41562396
DOI: 10.1002/1873-3468.70288

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