Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-strand conformation polymorphisms can be used to detect T cell receptor gene rearrangements: an application to the in vivo hprt mutation assay.

Mutagenesis - 1 Sept 1991

Caggana M, Benjamin M B, Little J B, Liber H L, Kelsey K T

Abstract excerpt

Epidemiologic application of the human in vivo hypoxanthine-guanine phosphoribosyltransferase (hprt) mutation assay requires screening of mutant colonies to differentiate independent from clonal origin. Previously, sibship was defined by Southern blot analysis of T cell receptor gene rearrangements. We report here a more expedient method to determine these rearrangements utilizing the polymerase chain reaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Nucleic Acid Conformation

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 1795641
DOI: 10.1093/mutage/6.5.375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-strand conformation polymorphisms can be used to detect T cell receptor gene rearrangements: an application to the in vivo hprt mutation assay.PMID 1795641Read ↗

Quantification and molecular characterization of hprt mutants of human T-lymphocytes.Semantic proximity Read ↗

Methods for detecting somatic mutations in vitro: the human T-cell cloning assay selecting for HPRT mutants.Semantic proximity Read ↗

DNA sequence analysis of in vivo hprt mutation in human T lymphocytes.Semantic proximity Read ↗

HPRT mutations in humans: biomarkers for mechanistic studies.Semantic proximity Read ↗

Southern blot analysis of T-cell receptor gene rearrangements in cynomolgus monkeys, and identification of a progenitor cell HPRT mutation.Semantic proximity Read ↗

Determination of hprt mutant and mutation frequencies and the molecular characterization of human derived in vivo T-lymphocyte mutants.Semantic proximity Read ↗

In vivo somatic mutations in human lymphocytes frequently result from major gene alterations.Semantic proximity Read ↗

Novel types of mutation identified at the hprt locus of human T-lymphocytes.Semantic proximity Read ↗

Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.Semantic proximity Read ↗

Southern-blot analyses of human T-lymphocyte mutants induced in vitro by gamma-irradiation.Semantic proximity Read ↗

Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.Semantic proximity Read ↗

Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.