Article
Southern blot analysis of T-cell receptor gene rearrangements in cynomolgus monkeys, and identification of a progenitor cell HPRT mutation.
Environmental and molecular mutagenesis - 1 Jan 1995
Mattano S S, Zimmer D M, Harbach P R, Hunter T C, Aaron C S
Abstract excerpt
Increases in peripheral blood T-lymphocyte HPRT mutant frequency may reflect either a number of independent HPRT gene mutational events or clonal proliferation of a single HPRT mutant. Sequence analysis of HPRT mutations in conjunction with T-cell receptor (TCR) gene rearrangement pattern analysi...
Topics
- Animals
- Antineoplastic Agents, Alkylating
- Base Composition
- Base Sequence
- Benzofurans
- Blotting, Southern
- Cells, Cultured
- Cloning, Molecular
- Cyclohexanecarboxylic Acids
- Cyclohexenes
- DNA Primers
- Drugs, Investigational
- Duocarmycins
- Gene Rearrangement, T-Lymphocyte
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Indoles
- Macaca fascicularis